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Indication & Dosage
 
 
Intravenous
AS AN ADJUNCT TO GENERAL ANAESTHESIA TO FACILITATE ENDOTRACHEAL INTUBATION AND TO RELAX SKELETAL MUSCLES DURING SURGERY OR MECHANICAL VENTILATION
Adult: Initially, 300-600 mcg/kg as inj. Subsequently, 100-200 mcg/kg when necessary or every 15-25 minutes for maintenance in prolonged procedures. Alternatively, maintenance can also be achieved by continuous infusion at 5-10 mcg/kg/minute.
 
Intravenous
MUSCLE RELAXANT IN GENERAL ANAESTHESIA
Adult: Initially, 300-600 mcg/kg as inj. Subsequently, 100-200 mcg/kg when necessary or every 15-25 minutes for maintenance in prolonged procedures. Alternatively, maintenance can also be achieved by continuous infusion at 5-10 mcg/kg/minute.
 
Intravenous
MUSCLE RELAXANT IN GENERAL ANAESTHESIA
Child: Initially, 300-600 mcg/kg as inj. Subsequently, 100-200 mcg/kg when necessary or every 15-25 minutes for maintenance in prolonged procedures. Alternatively, maintenance can also be achieved by continuous infusion at 5-10 mcg/kg/minute.
 
Intravenous
AS AN ADJUNCT TO GENERAL ANAESTHESIA TO FACILITATE ENDOTRACHEAL INTUBATION AND TO RELAX SKELETAL MUSCLES DURING SURGERY OR MECHANICAL VENTILATION
Child: ≥2 mth: Initially, 400-500 mcg/kg as inj. Maintenance dose: 80-100 mcg/kg; first maintenance dose may be given 20-45 min after the initial dose, subsequently, may be repeated every 15-25 min. For children 1 mth-2 yr: 300-400 mcg/kg may be used as initial dose in those who are under halothane anaesthesia. Maintenance doses may be admin more frequently in infant and children than adults.
   
Precautions Neonates; severe CVS disorders; renal or hepatic dysfunction; myasthenia gravis and other neuromuscular disorders; severe electrolyte imbalances; respiratory insufficiency or pulmonary disease, asthma; burns; cardiopulmonary bypass; smoking; pregnancy and lactation. Dosage for obese patients should be based on ideal body-weight to prevent overdosing.
   
Adverse Drug Reactions

Cutaneous reactions; bradycardia, transient hypotension in patients with CVS disorders; dyspnoea, bronchospasm; rash and urticaria.

   
Interactions Mixed block with suxamethonium which is difficult to reverse with anticholinergic drugs. Ketamine may potentiate the effects of atracurium. Concurrent use with tamoxifen or danazol may prolong effects of atracurium.
   
   
 

 

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